000 04488cam a22006254a 4500
999 _c535
_d535
001 99142530590001452
003 MACHS
005 20210413150458.0
008 031209s2004 dcua bf 001 0 eng
010 _a 2003026662
016 7 _a101200056
_2DNLM
020 _a1582120544
020 _a9781582120546
035 _a(OCoLC)53896589
035 _a(OCoLC)ocm53896589
035 _a(EXLNZ-01ALLIANCE_NETWORK)9998401530001451
040 _aDNLM/DLC
_beng
_cMACHS
_dYDX
042 _apcc
049 _aMAIN
050 0 0 _aRM301.5
_b.R57 2004
060 0 0 _a2004 H-729
060 1 0 _aQV 39
_bR612h 2004
082 0 0 _a615.7
_222
100 1 _aRitschel, W. A.
_q(Wolfgang A.)
245 1 0 _aHandbook of basic pharmacokinetics-- including clinical applications /
_cWolfgang A. Ritschel, Gregory L. Kearns.
250 _a6th ed.
260 _aWashington, D.C. :
_bAmerican Pharmacists Association,
_c©2004.
300 _axii, 432 pages :
_billustrations ;
_c26 cm
336 _atext
_btxt
_2rdacontent
337 _aunmediated
_bn
_2rdamedia
338 _avolume
_bnc
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aDefinitions and glossary -- The LADMER system: liberation, absorption, distribution, metabolism, elimination, and response -- Organs, tissues, cells, and organelles -- Cell membranes -- Drug-receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physicochemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system -- Binding of drugs to biological material -- Drug biotransformation -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling.
505 0 _aCumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Pediatric pharmacokinetics -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug disposition in pregnancy -- Dosage regimen design -- Drug monitoring and dosage adjustment -- Physiological and pathological factors influencing drug response -- First dosage size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface areas -- Extracorporeal methods of drug removal -- Pharmacogenetics and pharmacogenomics.
520 _aA user-friendly handbook on the principles and techniques involved in the various applications of pharmacokinetics. Provides a concise reference for clinicians who need quick information on the pharmacokinetic characteristics of specific drugs. Thoroughly updated and revised, this book features pharmacokinetic data profiles on more than 600 drugs.
650 0 _aPharmacokinetics
_vHandbooks, manuals, etc.
650 0 _aClinical pharmacology
_vHandbooks, manuals, etc.
650 1 2 _aPharmacokinetics.
650 6 _aPharmacocinétique
_vGuides, manuels, etc.
650 6 _aPharmacologie clinique
_vGuides, manuels, etc.
650 7 _aClinical pharmacology.
_2fast
_0(OCoLC)fst00864398
650 7 _aPharmacokinetics.
_2fast
_0(OCoLC)fst01060250
650 7 _aFarmacocinética.
_2larpcal
655 2 _aHandbooks.
655 7 _aHandbooks and manuals.
_2fast
_0(OCoLC)fst01423877
700 1 _aKearns, Gregory L.
710 2 _aAmerican Pharmaceutical Association.
776 0 8 _iOnline version:
_aRitschel, W.A. (Wolfgang A.).
_tHandbook of basic pharmacokinetics-- including clinical applications.
_b6th ed.
_dWashington, D.C. : American Pharmacists Association, ©2004
_w(OCoLC)607387019
776 0 8 _iOnline version:
_aRitschel, W.A. (Wolfgang A.).
_tHandbook of basic pharmacokinetics-- including clinical applications.
_b6th ed.
_dWashington, D.C. : American Pharmacists Association, ©2004
_w(OCoLC)609118727
856 4 1 _3Table of contents
_uhttp://catdir.loc.gov/catdir/toc/ecip0412/2003026662.html
856 4 2 _3Book review (E-STREAMS)
_uhttp://www.e-streams.com/es0712/es0712_3810.html
856 4 2 _3Publisher description
_uhttp://catdir.loc.gov/catdir/description/mh041/2003026662.html
942 _2lcc
_cBK