Handbook of basic pharmacokinetics-- including clinical applications / Wolfgang A. Ritschel, Gregory L. Kearns.

Includes bibliographical references and index.

Definitions and glossary -- The LADMER system: liberation, absorption, distribution, metabolism, elimination, and response -- Organs, tissues, cells, and organelles -- Cell membranes -- Drug-receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physicochemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system -- Binding of drugs to biological material -- Drug biotransformation -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling.

Cumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Pediatric pharmacokinetics -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug disposition in pregnancy -- Dosage regimen design -- Drug monitoring and dosage adjustment -- Physiological and pathological factors influencing drug response -- First dosage size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface areas -- Extracorporeal methods of drug removal -- Pharmacogenetics and pharmacogenomics.

A user-friendly handbook on the principles and techniques involved in the various applications of pharmacokinetics. Provides a concise reference for clinicians who need quick information on the pharmacokinetic characteristics of specific drugs. Thoroughly updated and revised, this book features pharmacokinetic data profiles on more than 600 drugs.